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06:21, 21 October 2025
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Russian Scientists Develop AI System to Diagnose Brain Tumors

The technology identifies tumor subtypes and helps doctors choose personalized treatment strategies.

Researchers at Lobachevsky State University of Nizhny Novgorod have created an artificial intelligence system capable of accurately diagnosing subtypes of gliomas — one of the most aggressive forms of brain cancer. The innovation could help doctors make faster, more precise diagnoses and select optimal therapies for each patient.

“Traditional glioma diagnostics don’t always allow doctors to quickly and accurately identify the tumor type,” explained Mikhail Ivanchenko, director of the university’s Institute of Biology of Aging. “Histological tests and genetic screenings can yield conflicting results, and even advanced MRI protocols often fall short because of the tumors’ heterogeneity. Our system analyzes tumor data at the transcriptomic level — it determines which genes are ‘switched on’ or ‘off’ and measures their activity for each patient. This helps pinpoint the glioma subtype and guide the doctor toward the most effective treatment.”

The Nizhny Novgorod team’s AI model evaluates the activity of 13 key genes linked to three major glioma subtypes. By mapping the genetic “on/off” patterns, the system produces a more accurate diagnosis tailored to the individual.

Transparent AI — No “Black Boxes”

Unlike many AI tools that operate as opaque “black boxes,” the researchers built their model on the principle of explainable artificial intelligence. The system clearly shows how each of the 13 genes influences its final decision, giving physicians insight into the algorithm’s reasoning and supporting their own clinical judgment.

The technology opens new possibilities for personalized oncology, where treatment is based on the unique biological profile of each patient. While the system is currently used in research settings, the team plans to develop clinical diagnostic kits in the future — a step that could dramatically speed up cancer detection and improve patient outcomes.

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