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15:30, 03 December 2025
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Russian Scientists Create a “DNA Error Detector” for More Accurate Genetic Analysis

A new digital tool developed in Russia enhances the accuracy of genetic research by identifying errors in nanopore-based DNA sequencing

Researchers at Moscow State University have introduced a software solution designed to detect errors during DNA reading. The development aims to improve the reliability of experiments in genetics, personalized medicine, and drug discovery.

The team created a web service called NanoporeInspect, which simplifies the workflow of nanopore sequencing — a method that allows scientists to read long strands of DNA and RNA. For accurate analysis, artificial tags must be attached to molecules, but incorrect tag placement can distort results, according to TASS.

“The program allows users to specify the required artificial sequences and see their distribution across the reads. If adapters or barcodes are attached with errors, this becomes immediately visible on interactive graphs,” explained Maria Grigorieva, project co‑author and lead specialist at the university’s Laboratory of Mathematical Modeling.

A Path to Breakthrough Discoveries

The service works simply: the researcher uploads sequencing results and specifies which tags were used. Algorithms analyze the data and generate visualizations that help assess material quality at the earliest stage — essentially allowing scientists to judge the “quality of the book” before reading it. In genetic studies, such precision is critical, MSU experts emphasize.

Implementing this technology holds major importance for global medicine. It introduces a new standard of quality control in genomic research, accelerating breakthroughs in combating hereditary diseases, viruses, and in developing new therapeutics.

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